Simpkins is a surname, and may refer to:
- Andy Simpkins (1932–1999), American jazz musician
- C. O. Simpkins (b. 1947), American physician, biographer, and historian
- Charles Simpkins (b. 1963), American Olympic athlete
- Chris Simpkins (contemporary), Chief Executive of the Falkland Islands 2003–2007
- Dickey Simpkins (b. 1972), American professional basketball player
- James Simpkins (b. unknown, d. 2004), Canadian cartoonist and artist
- John Simpkins (1862–1898), American politician from Massachusetts; U.S. representative 1895–98
- Luke Simpkins (b. 1964), Australian politician from Western Australia
- Michael Simpkins (b. 1978), English professional football player
- Paul Simpkins (contemporary), Australian professional rugby league referee
- Ron Simpkins (b. 1958), American professional football player
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