SF3A3

SF3A3

Identifiers Symbols SF3A3; PRP9; PRPF9; SAP61; SF3a60 External IDs OMIM: 605596 MGI: 1922312 HomoloGene: 4949 GeneCards: SF3A3 Gene

Gene Ontology
Molecular function	• nucleic acid binding • protein binding • zinc ion binding
Cellular component	• nucleus • nucleoplasm • spliceosomal complex • nucleolus • nuclear speck • catalytic step 2 spliceosome
Biological process	• RNA splicing, via transesterification reactions • mRNA 3'-splice site recognition • mRNA splicing, via spliceosome • mRNA processing • RNA splicing • gene expression
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 10946 75062 Ensembl ENSG00000183431 ENSMUSG00000028902 UniProt Q12874 Q9D554 RefSeq (mRNA) NM_006802 NM_029157 RefSeq (protein) NP_006793 NP_083433 Location (UCSC) Chr 1:
38.42 – 38.46 Mb Chr 4:
124.71 – 124.73 Mb PubMed search

Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.

This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20.