Sesa is a municipality located in the Hoya de Huesca comarca, province of Huesca, Aragon, Spain. According to the 2010 census the municipality has a population of 225 inhabitants. Its postal code is 22110.
There is an ancient Iberian archaeological site at a place known as "El Portillo", located within Sesa's municipal term. In the Middle Ages there was an important castle in Sesa.