Serum and Glucocorticoid Induced Kinase

Serum And Glucocorticoid Induced Kinase

Identifiers Symbols SGK1; SGK External IDs OMIM: 602958 MGI: 1340062 HomoloGene: 48364 ChEMBL: 2343 GeneCards: SGK1 Gene EC number 2.7.11.1

Gene Ontology
Molecular function	• protein serine/threonine kinase activity • calcium channel regulator activity • ATP binding • potassium channel regulator activity • sodium channel regulator activity • chloride channel regulator activity
Cellular component	• nucleus • mitochondrion • endoplasmic reticulum membrane • cytosol • plasma membrane
Biological process	• regulation of cell growth • protein phosphorylation • sodium ion transport • apoptotic process • response to stress • response to DNA damage stimulus • long-term memory • regulation of blood pressure • regulation of cell migration • positive regulation of transporter activity • ion transmembrane transport • regulation of cell proliferation • regulation of apoptotic process • regulation of catalytic activity • regulation of sequence-specific DNA binding transcription factor activity • transmembrane transport • regulation of gastric acid secretion • renal sodium ion absorption
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6446 20393 Ensembl ENSG00000118515 ENSMUSG00000019970 UniProt O00141 Q9WVC6 RefSeq (mRNA) NM_001143676 NM_001161845 RefSeq (protein) NP_001137148 NP_001155317 Location (UCSC) Chr 6:
134.49 – 134.64 Mb Chr 10:
21.88 – 22 Mb PubMed search

Serine/threonine-protein kinase SGK is a kinase subfamily that is known as being encoded by SGK1, SGK2, and SGK3 genes.

Among the three SGK genes, SGK1 is the most intensively studied. This gene encodes a serine/threonine protein kinase that is highly similar to the rat serum-and glucocorticoid-induced protein kinase (SGK). This gene was identified in a screen of hepatocellular genes regulated in response to cellular hydration or swelling. Cellular hydration is a catabolic signal, stimulating glycogenolysis and proteolysis, and inhibiting protein and glycogen synthesis. This kinase has been shown to be important in activating certain potassium, sodium, and chloride channels. Expression of this gene in hepatocytes is stimulated by transforming growth factor-beta (TGF-beta) which participates in the pathophysiology of diabetic complications. Since both TGF-beta expression and SGK expression are elevated in diabetic nephropathy, this suggests an involvement of SGK in the development of this condition.

The SGK1 kinase regulates the myo-inositol transporter during osmotic stress.

Deregulated expression of SGK1 in the endometrium has been implicated in cases of infertility or recurrent miscarriage in humans, and SGK1 expression in the endometrium also affects fertility in mice.