Protein Structure Prediction
The 3D structures of molecules are of great importance to their functions in nature. Since structural prediction of large molecules at an atomic level is largely intractable problem, some biologists introduced ways to predict 3D structure at a primary sequence level. This includes biochemical or statistical analysis of amino acid residues in local regions and structural inference from homologs (or other potentially related proteins) with known 3D structures.
There have been a large number of diverse approaches to solve the structure prediction problem. In order to determine which methods were most effective a structure prediction competition was founded called CASP (Critical Assessment of Structure Prediction).
Read more about this topic: Sequence Analysis
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