SC4 may refer to:
- SC-4, a fictional shuttlecraft that featured in Star Trek: Voyager's series finale, "Endgame"; see Shuttlecraft (Star Trek)#SC-4
- SimCity 4, a city-building simulation computer game
- Soulcalibur IV, the sixth installment in Namco's Soul series of fighting games
- St. Clair County Community College, a two-year community college located in Port Huron, Michigan
- Tom Clancy's Splinter Cell: Double Agent, the fourth installment in the Splinter Cell series of video games
- USS SC-4, a United States Navy submarine chaser commissioned in 1918 and sold in 1920