Sapho may refer to:
- Sapho (novel) (1884), by Alphonse Daudet
- Sapho (Massenet), 1897 opera by Jules Massenet, based on Daudet's novel
- Sapho (Gounod), 1851 opera by Charles Gounod
- Sapho (play), 1900 play by Clyde Fitch
- Queen Sapho, a main character in the 1584(?) Elizabethan play Sapho and Phao
- Sapho genus of Damselflies
- SAPHO syndrome, chronic disease with synovitis, acne, pustulosis, hyperostosis and osteitis
- Madeleine de Scudéry (1607-1701), French writer who used the pseudonym Sapho
- Sapho (singer), French singer
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