Software
- SAM Broadcaster
- SAM card (Security Authentication Module card), a small smart card used to hold cryptographic keys
- Sam (text editor), a text editor by Rob Pike
- San Andreas Multiplayer, the multiplayer feature on GTA: San Andreas
- Secure access module
- Security Accounts Manager, the accounts database used by Microsoft Windows NT, Windows 2000, and later Microsoft operating systems
- Sequential access memory, a class of storage devices that are read sequentially
- Simple Anonymous Messaging, a protocol specification used in the I2P network layer
- SlideME Application Manager, the native Android Application for the SlideME alternative Android application market
- Software asset management
- Software Automatic Mouth, a computer program for speech synthesis
- Microsoft Sam, the default voice for the screen reader program in Windows 2000 and Windows XP
- Symantec Anti-Virus for Macintosh
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