| Gene Ontology | |
|---|---|
| Molecular function | • calcium ion binding • protein binding • microtubule binding • zinc ion binding • Toll-like receptor 4 binding • arachidonic acid binding • RAGE receptor binding |
| Cellular component | • extracellular region • extracellular space • cytosol • cytoskeleton • plasma membrane |
| Biological process | • cytokine production • leukocyte migration involved in inflammatory response • acute inflammatory response • chronic inflammatory response • autophagy • induction of apoptosis • activation of cysteine-type endopeptidase activity involved in apoptotic process • inflammatory response • response to zinc ion • positive regulation of cell growth • neutrophil chemotaxis • sequestering of zinc ion • response to lipopolysaccharide • chemokine production • wound healing • defense response to bacterium • innate immune response • response to ethanol • positive regulation of inflammatory response • defense response to fungus • positive regulation of NF-kappaB transcription factor activity • regulation of cytoskeleton organization • neutrophil aggregation |
| Sources: Amigo / QuickGO | |
153.36 – 153.36 Mb
90.67 – 90.67 Mb
Protein S100-A8 is a protein that in humans is encoded by the S100A8 gene.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.
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