RRM1

RRM1

Identifiers Symbols RRM1; R1; RIR1; RR1 External IDs OMIM: 180410 MGI: 98180 HomoloGene: 806 ChEMBL: 1830 GeneCards: RRM1 Gene EC number 1.17.4.1

Gene Ontology
Molecular function	• ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor • protein binding • ATP binding
Cellular component	• nucleoplasm • cytosol • ribonucleoside-diphosphate reductase complex
Biological process	• DNA replication • deoxyribonucleotide biosynthetic process • nucleobase-containing small molecule interconversion • small molecule metabolic process • protein heterotetramerization • nucleobase-containing small molecule metabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6240 20133 Ensembl ENSG00000167325 ENSMUSG00000030978 UniProt P23921 P07742 RefSeq (mRNA) NM_001033 NM_009103 RefSeq (protein) NP_001024 NP_033129 Location (UCSC) Chr 11:
4.12 – 4.16 Mb Chr 7:
102.44 – 102.47 Mb PubMed search

Ribonucleoside-diphosphate reductase large subunit is an enzyme that in humans is encoded by the RRM1 gene.

This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.