RICS (gene)

RICS (gene)

Identifiers Symbols ARHGAP32; GC-GAP; GRIT; PX-RICS; RICS; p200RhoGAP; p250GAP External IDs OMIM: 608541 MGI: 2450166 HomoloGene: 8812 GeneCards: ARHGAP32 Gene

Gene Ontology
Molecular function GTPase activator activity
protein binding
phosphatidylinositol binding
Cellular component Golgi membrane
endoplasmic reticulum membrane
cytosol
plasma membrane
cell cortex
endosome membrane
postsynaptic density
actin cytoskeleton
cell junction
postsynaptic membrane
Biological process small GTPase mediated signal transduction
regulation of small GTPase mediated signal transduction
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 9743 330914 Ensembl ENSG00000134909 ENSMUSG00000041444 UniProt A7KAX9 Q811P8 RefSeq (mRNA) NM_001142685 NM_001195632 RefSeq (protein) NP_001136157 NP_001182561 Location (UCSC) Chr 11:
128.83 – 129.15 Mb Chr 9:
32.12 – 32.27 Mb PubMed search

Rho GTPase-activating protein 32 is a protein that in humans is encoded by the RICS gene. RICS has two known isoforms, RICS that are expressed primarily at neurite growth cones, and at the post synaptic membranes, and PX-RICS which is more widely expressed in the endoplasmic reticulum, Golgi apparatus and endosomes. The only known domain of the RICS is the RhoGAP domain, whilst PX-RICS has an additional Phox homology and SH3 domain.

Read more about RICS (gene):  Function, Interactions