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- Ed Rice (1918–2001), U.S. author, publisher, photojournalist and painter
- Ed Rice (born 1977), U.K. long-term pension salesman, international experience in pure commission roles mainly in Dubai
- Edmund Ignatius Rice (1762–1844), Irish Roman Catholic missionary, founder of Christian Brothers and Presentation Brothers
- Edmund Rice (1638) (1594–1663), early Massachusetts Bay settler who has many descendants in the northern U.S.A.
- Edmund Rice (general) (1842–1906), brigadier general, American Civil War Medal of Honor recipient
- Edmund Rice (politician) (1819–1889), U.S. Congressman from Minnesota
- Edward A. Rice, Jr. (born 1955), U.S. Air Force Lt. General
- Edward E. Rice (1847–1924), writer in U.S. theater
- Edward Loranus Rice (1871–1960), U.S. biologist and educator
- Edward Y. Rice (1820–1883), U.S. representative from Illinois
- Elliott Warren Rice (1835–1887), U.S. Civil War general (Union)
- Elmer Rice (1892–1967), U.S. Pulitzer Prize winning playwright
- Eugene Rice (1891-1967, U.S. federal judge.
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