Ribosomal Protein - Disposition in The Small Ribosomal Subunit

Disposition in The Small Ribosomal Subunit

In the small (30S) subunit of E. coli ribosomes, the proteins denoted S4, S7, S8, S15, S17, S20 bind independently to 16S rRNA. After assembly of these primary binding proteins, S5, S6, S9, S12, S13, S16, S18, and S19 bind to the growing ribosome. These proteins also potentiate the addition of S2, S3, S10, S11, S14, and S21. Protein binding to helical junctions is important for initiating the correct tertiary fold of RNA and to organize the overall structure. Nearly all the proteins contain one or more globular domains. Moreover, nearly all contain long extensions that can contact the RNA in far-reaching regions. Additional stabilization results from the proteins' basic residues, as these neutralize the charge repulsion of the RNA backbone. Protein-protein interactions also exist to hold structure together by electrostatic and hydrogen bonding interactions. Theoretical investigations pointed to correlated effects of protein-binding onto binding affinities during the assembly process

Read more about this topic:  Ribosomal Protein

Famous quotes containing the words disposition and/or small:

    We tried pathetic appeals to the wandering waiters, who told us “they are coming, Sir” in a soothing tone—and we tried stern remonstrance, & they then said “they are coming, Sir” in a more injured tone; & after all such appeals they retired into their dens, and hid themselves behind sideboards and dish-covers, still the chops came not. We agreed that of all virtues a waiter can display, that of a retiring disposition is quite the least desirable.
    Lewis Carroll [Charles Lutwidge Dodgson] (1832–1898)

    no little brass rollers
    and small easy wheels on the bottom—
    my townspeople what are you thinking of!
    A rough plain hearse then
    with gilt wheels and no top at all.
    William Carlos Williams (1883–1963)