Rev-Erb A Beta

Rev-Erb A Beta

Identifiers Symbols NR1D2; BD73; EAR-1R; RVR External IDs OMIM: 602304 MGI: 2449205 HomoloGene: 3763 IUPHAR: NR1D2 GeneCards: NR1D2 Gene

Gene Ontology
Molecular function	• steroid hormone receptor activity • ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity • zinc ion binding • sequence-specific DNA binding
Cellular component	• nucleus • nucleoplasm
Biological process	• regulation of transcription, DNA-dependent • transcription initiation from RNA polymerase II promoter • gene expression • intracellular receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 9975 353187 Ensembl ENSG00000174738 ENSMUSG00000021775 UniProt Q14995 Q60674 RefSeq (mRNA) NM_001145425 NM_011584 RefSeq (protein) NP_001138897 NP_035714 Location (UCSC) Chr 3:
23.99 – 24.02 Mb Chr 14:
18.2 – 18.24 Mb PubMed search

Rev-ErbA beta (Rev-erbβ) also known as NR1D2 (nuclear receptor subfamily 1, group D, member 2) is a protein that in humans is encoded by the NR1D2 gene.

Rev-erbβ is a member of the Rev-ErbA family of transcription factors. Rev-erbβ, like Rev-erbα, belongs to the nuclear receptor superfamily and can modulate gene expression by directly binding to their promoters.