Rev-Erb A Alpha

Rev-Erb A Alpha

Identifiers Symbols NR1D1; EAR1; THRA1; THRAL; ear-1; hRev External IDs OMIM: 602408 MGI: 2444210 HomoloGene: 23324 IUPHAR: NR1D1 GeneCards: NR1D1 Gene

Gene Ontology
Molecular function	• steroid hormone receptor activity • transcription corepressor activity • ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity • zinc ion binding • sequence-specific DNA binding • transcription regulatory region DNA binding
Cellular component	• nuclear chromatin • nucleus • nucleoplasm
Biological process	• negative regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • circadian rhythm • gene expression • negative regulation of receptor biosynthetic process • intracellular receptor signaling pathway • negative regulation of toll-like receptor 4 signaling pathway • cellular response to lipopolysaccharide • positive regulation of cholesterol homeostasis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 9572 217166 Ensembl ENSG00000126368 ENSMUSG00000020889 UniProt P20393 Q3UV55 RefSeq (mRNA) NM_021724 NM_145434 RefSeq (protein) NP_068370 NP_663409 Location (UCSC) Chr 17:
38.25 – 38.26 Mb Chr 11:
98.77 – 98.78 Mb PubMed search

Rev-ErbA alpha also known as NR1D1 (nuclear receptor subfamily 1, group D, member 1), is a protein that in humans is encoded by the NR1D1 gene.

Rev-erbα is member of the Rev-ErbA family of nuclear receptors and is a transcriptional repressor. In mammals, Rev-erbα is highly expressed in the liver, skeletal muscle, adipose tissue, and the brain, participating in the development and circadian regulation of these tissues.