The repression of heat shock gene expression (ROSE) element is an RNA element found in the 5' UTR of some heat shock protein's mRNAs. The ROSE element is an RNA thermometer that negatively regulates heat shock gene expression. The secondary structure is thought to be altered by temperature, thus it is an RNA thermometer. This structure blocks access to the ribosome binding site at normal temperatures. During heat shock however, the structure changes freeing the ribosome binding site and allowing expression to occur.
A partial structure of this RNA element has been determined using NMR.
Read more about Repression Of Heat Shock Gene Expression (ROSE) Element: ROSE1 and ROSEAT2, See Also
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