Referred Itch - Management

Management

The origin of referred itch is unknown, whether it be neuropathic (originating at in the brain), pruritoceptic (originating at the skin), or disease related, so treatment for it specifically still remains unclear. Nevertheless, treatment for different kinds of itch, some of which may be applicable to referred itch, are available. Note that people with this symptom should seek medical care and consult appropriate medications with a doctor.

Though topical corticosteroids alleviate itching, especially itch secondary to inflammatory skin disease, they are not direct antipruritics. Treating itch originating at the skin can sufficiently be treated topically with capsaicin cream, doxepin, and aspirin. Capsiacin works by desensitizing nerve endings that are particular to irritable stimuli. Doxepin, a highly potent antihistamine, in topical form has also been proven in placebo-controlled double blind studies to relieve itch associated with atopic eczema. Other topical antidepressants such as amitriptyline and diphenhydramine are proved to partially relieve histamine-induced itch. However, such antidepressant and anti-anxiety medication can cause other side effects, so one should first consult with a doctor before using any of these medications. Topical aspirin is thought to help relieve itch as well. Aspirin taken orally has minimal effect on itch.

Therapeutic options for itch that originates in the central nervous system are limited, and need further confirmation, but are in general based on the counteracting interaction between itch and pain via the spine. Treatments of low dosage lidocaine and gabapentin might be effective in relieving itch that is thought to originate in the central nervous system.