Reactive Nitrogen Species - Types

Types

RNS are produced in animals starting with the reaction of nitric oxide (·NO) with superoxide (O2·−) to form peroxynitrite (ONOO−):

  • ·NO (nitric oxide) + O2·− (superoxide) → ONOO− (peroxynitrite)

Superoxide anion (O2-) is a reactive oxygen species that reacts quickly with nitric oxide (NO) in the vasculature. The reaction produces peroxynitrite and depletes the bioactivity of NO. This is important because NO is a key mediator in many important vascular functions including regulation of smooth muscle tone and blood pressure, platelet activation, and vascular cell signaling.

Peroxynitrite itself is a highly reactive species which can directly react with various biological targets and components of the cell including lipids, thiols, amino acid residues, DNA bases, and low-molecular weight antioxidants. However, these reactions happen at a relatively slow rate. This slow reaction rate allows it to react more selectively throughout the cell. Peroxynitrite is able to get across cell membranes to some extent through anion channels. Additionally peroxynitrite can react with other molecules to form additional types of RNS including nitrogen dioxide (·NO2) and dinitrogen trioxide (N2O3) as well as other types of chemically reactive free radicals. Important reactions involving RNS include:

  • ONOO− + H+ → ONOOH (peroxynitrous acid) → ·NO2 (nitrogen dioxide) + ·OH (hydroxyl radical)
  • ONOO− + CO2 (carbon dioxide) → ONOOCO2− (nitrosoperoxycarbonate)
  • ONOOCO2− → ·NO2 (nitrogen dioxide) + O=C(O·)O− (carbonate radical)
  • ·NO + ·NO2 N2O3 (dinitrogen trioxide)

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