Subjects For Scientific Research
In 1895, Clark University in Worcester, Massachusetts (United States) established a population of domestic albino brown rats to study the effects of diet and for other physiological studies. Over the years, rats have been used in many experimental studies, which have added to our understanding of genetics, diseases, the effects of drugs, and other topics that have provided a great benefit for the health and well-being of humankind. Laboratory rats have also proved valuable in psychological studies of learning and other mental processes (Barnett, 2002), as well as to understand group behavior and overcrowding (with the work of John B. Calhoun on behavioral sink). A 2007 study found rats to possess metacognition, a mental ability previously only documented in humans and some primates.
Domestic rats differ from wild rats in many ways. They are calmer and less likely to bite; they can tolerate greater crowding; they breed earlier and produce more offspring; and their brains, livers, kidneys, adrenal glands, and hearts are smaller (Barnett 2002).
Brown rats are often used as model organisms for scientific research. Since the publication of the rat genome sequence, and other advances, such as the creation of a rat SNP chip, and the production of knockout rats, the laboratory rat has become a useful genetic tool, although not as popular as mice. When it comes to conducting tests related to intelligence, learning, and drug abuse, rats are a popular choice due to their high intelligence, ingenuity, aggressiveness, and adaptability. Their psychology, in many ways, seems to be similar to humans. Entirely new breeds or "lines" of brown rats, such as the Wistar rat, have been bred for use in laboratories. Much of the genome of Rattus norvegicus has been sequenced.
Read more about this topic: Rat
Famous quotes containing the words subjects for, subjects, scientific and/or research:
“Christmas and Easter can be subjects for poetry, but Good Friday, like Auschwitz, cannot. The reality is so horrible, it is not surprising that people should have found it a stumbling block to faith.”
—W.H. (Wystan Hugh)
“The beasts, the fishes, and the winged fowls
Are their males’ subjects and at their controls:
Man, more divine, the master of all these,
Lord of the wide world and wild watery seas,
Indued with intellectual sense and souls,
Of more pre-eminence than fish and fowls,
Are masters to their females, and their lords:
Then let your will attend on their accords.”
—William Shakespeare (1564–1616)
“The besetting sin of able men is impatience of contradiction and of criticism. Even those who do their best to resist the temptation, yield to it almost unconsciously and become the tools of toadies and flatterers. “Authorities,” “disciples,” and “schools” are the curse of science and do more to interfere with the work of the scientific spirit than all its enemies.”
—Thomas Henry Huxley (1825–95)
“Our science has become terrible, our research dangerous, our findings deadly. We physicists have to make peace with reality. Reality is not as strong as we are. We will ruin reality.”
—Friedrich Dürrenmatt (1921–1990)