Indications For Use
Ranolazine is indicated for the treatment of chronic angina; it may be used in combination with beta blockers, nitrates, calcium channel blockers, antiplatelet therapy, lipid-lowering therapy, ACE inhibitors, and angiotensin receptor blockers. It has been shown to decrease angina episodes in individuals with coronary artery disease on maximal doses of amlodipine. In addition, it has been shown to both decrease angina episodes and increase exercise tolerance in individuals taking concomitant atenolol, amlodipine, or diltiazem.
Unlike other antianginal medications, such as nitrates and beta blockers, ranolazine does not significantly alter either the heart rate or blood pressure, so it is of particular use in individuals with angina who are not responsive to maximal tolerated doses of other antianginal medications.
While it would seem from the mechanism of action that ranolazine may be of benefit in individuals with non-ST-elevation acute coronary syndromes and acute myocardial infarction (heart attack), the recently completed Merlin/TIMI-36 trial showed no benefit in this population.
Read more about this topic: Ranolazine
Famous quotes containing the word indications:
“The indications are that swearing preceded the development of cursing. That is, expletives, maledictions, exclamations, and imprecations of the immediately explosive or vituperative kind preceded the speechmaking and later rituals involved in the deliberate apportioning of the fate of an enemy. Swearing of the former variety is from the lips only, but the latter is from the heart. Damn it! is not that same as Damn you!”
—Ashley Montagu (b. 1905)