RACK is an acronym for Receptor for Activated C-Kinase and is responsible for the binding of active forms of the protein kinase C (PKC) family of enzymes. See also RICK protein, Receptor for Inactive C-Kinase.
There are different RACKs for different isoforms of PKC, which thus mediate differential subcellular targeting of the isoforms.
Inactive forms of PKC occlude the RACK binding site with a pseudo-RACK peptide sequence
RACKs share 47% identity with the beta subunit of G proteins
RACKs represent one of the many ways in which a cell can use signalling complexes to manipulate the specificity of interactions within intracellular signalling cascades
Famous quotes containing the words rack and/or protein:
“O, let him pass. He hates him
That would upon the rack of this tough world
Stretch him out longer.”
—William Shakespeare (1564–1616)
“Firm-style bean curd insoles cushion feet, absorb perspiration and provide more protein than meat or fish innersoles of twice the weight. Tofu compresses with use, becoming more pungent and flavorful. May be removed when not in use to dry or marinate. Innersoles are ready to eat after 1,200 miles of wear. Each pair provides adult protein requirement for 2 meals. Insoles are sized large to allow for snacks. Recipe booklet included.”
—Alfred Gingold, U.S. humorist. Items From Our Catalogue, “Tofu Innersoles,” Avon Books (1982)