Mechanism of Action
Pyrantel is a nicotinic receptor agonist. Like levamisole and the related pyrimidine morantel, it can elicit spastic muscle paralysis in parasitic worms due to prolonged activation of the excitatory nicotinic acetylcholine (nACh) receptors on body wall muscle. This has been studied in body wall muscle preparation of the parasitic nematode Ascaris.
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