PVRL3

PVRL3

Identifiers Symbols PVRL3; CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRR3 External IDs OMIM: 607147 HomoloGene: 9162 GeneCards: PVRL3 Gene

Gene Ontology
Molecular function protein binding
protein homodimerization activity
cell adhesion molecule binding
Cellular component plasma membrane
cell-cell adherens junction
integral to membrane
apical junction complex
Biological process lens morphogenesis in camera-type eye
homophilic cell adhesion
fertilization
cell junction assembly
adherens junction organization
cell-cell junction organization
retina morphogenesis in camera-type eye
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 25945 58998 Ensembl ENSG00000177707 ENSMUSG00000022656 UniProt Q9NQS3 Q9JLB9 RefSeq (mRNA) NM_001243286 NM_021495 RefSeq (protein) NP_001230215 NP_067470 Location (UCSC) Chr 3:
110.79 – 110.99 Mb Chr 16:
46.39 – 46.5 Mb PubMed search

Poliovirus receptor-related 3 (nectin-3), also known as PVRL3 and CD113 (Cluster of Differentiation 113), is a human gene.

Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090)-catenin (see MIM 116805) system in epithelial cells.

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