PTPN6

PTPN6

Identifiers Symbols PTPN6; HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1 External IDs OMIM: 176883 MGI: 96055 HomoloGene: 56589 ChEMBL: 3166 GeneCards: PTPN6 Gene EC number 3.1.3.48

Gene Ontology
Molecular function	• protein tyrosine phosphatase activity • transmembrane receptor protein tyrosine phosphatase activity • protein binding • protein kinase binding
Cellular component	• nucleus • cytoplasm • cytosol • membrane
Biological process	• protein dephosphorylation • apoptotic process • G-protein coupled receptor signaling pathway • blood coagulation • cell proliferation • positive regulation of cell proliferation • negative regulation of cell proliferation • positive regulation of phosphatidylinositol 3-kinase cascade • peptidyl-tyrosine phosphorylation • cytokine-mediated signaling pathway • cell differentiation • T cell costimulation • peptidyl-tyrosine dephosphorylation • negative regulation of peptidyl-tyrosine phosphorylation • leukocyte migration • interferon-gamma-mediated signaling pathway • regulation of interferon-gamma-mediated signaling pathway • type I interferon-mediated signaling pathway • regulation of type I interferon-mediated signaling pathway • JAK-STAT cascade involved in growth hormone signaling pathway • regulation of ERK1 and ERK2 cascade • regulation of G1/S transition of mitotic cell cycle
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5777 15170 Ensembl ENSG00000111679 ENSMUSG00000004266 UniProt P29350 P29351 RefSeq (mRNA) NM_002831 NM_001077705 RefSeq (protein) NP_002822 NP_001071173 Location (UCSC) Chr 12:
7.06 – 7.07 Mb Chr 6:
124.72 – 124.74 Mb PubMed search

Tyrosine-protein phosphatase non-receptor type 6 also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1) is an enzyme that in humans is encoded by the PTPN6 gene.