PSMD10
Gene Ontology | |
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Molecular function | • protein binding • transcription factor binding |
Cellular component | • proteasome complex • nucleus • nucleoplasm • cytoplasm • cytosol • proteasome regulatory particle • proteasome regulatory particle, base subcomplex • actin cytoskeleton • intermediate filament cytoskeleton |
Biological process | • cell cycle checkpoint • G1/S transition of mitotic cell cycle • S phase of mitotic cell cycle • M phase of mitotic cell cycle • mitotic anaphase • negative regulation of transcription from RNA polymerase II promoter • protein polyubiquitination • mitotic cell cycle • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • regulation of cellular amino acid metabolic process • apoptotic process • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • cytoplasmic sequestering of NF-kappaB • gene expression • viral reproduction • RNA metabolic process • mRNA metabolic process • positive regulation of cell growth • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • positive regulation of protein ubiquitination • negative regulation of NF-kappaB transcription factor activity • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • cellular nitrogen compound metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I • regulation of apoptotic process • negative regulation of apoptotic process • negative regulation of MAPK cascade • negative regulation of DNA damage response, signal transduction by p53 class mediator • small molecule metabolic process • positive regulation of cyclin-dependent protein kinase activity • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • proteasome regulatory particle assembly • negative regulation of release of cytochrome c from mitochondria |
Sources: Amigo / QuickGO |
107.33 – 107.33 Mb
140.95 – 140.96 Mb
26S proteasome non-ATPase regulatory subunit 10 is an enzyme that in humans is encoded by the PSMD10 gene.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.
Read more about PSMD10: Interactions