PSMD10

PSMD10

Identifiers Symbols PSMD10; dJ889N15.2; p28; p28(GANK) External IDs OMIM: 603480 MGI: 1858898 HomoloGene: 94517 GeneCards: PSMD10 Gene

Gene Ontology
Molecular function protein binding
transcription factor binding
Cellular component proteasome complex
nucleus
nucleoplasm
cytoplasm
cytosol
proteasome regulatory particle
proteasome regulatory particle, base subcomplex
actin cytoskeleton
intermediate filament cytoskeleton
Biological process cell cycle checkpoint
G1/S transition of mitotic cell cycle
S phase of mitotic cell cycle
M phase of mitotic cell cycle
mitotic anaphase
negative regulation of transcription from RNA polymerase II promoter
protein polyubiquitination
mitotic cell cycle
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
regulation of cellular amino acid metabolic process
apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
cytoplasmic sequestering of NF-kappaB
gene expression
viral reproduction
RNA metabolic process
mRNA metabolic process
positive regulation of cell growth
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein ubiquitination
negative regulation of NF-kappaB transcription factor activity
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular nitrogen compound metabolic process
antigen processing and presentation of exogenous peptide antigen via MHC class I
regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of MAPK cascade
negative regulation of DNA damage response, signal transduction by p53 class mediator
small molecule metabolic process
positive regulation of cyclin-dependent protein kinase activity
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
proteasome regulatory particle assembly
negative regulation of release of cytochrome c from mitochondria
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5716 53380 Ensembl ENSG00000101843 ENSMUSG00000031429 UniProt O75832 Q9Z2X2 RefSeq (mRNA) NM_002814 NM_001164177 RefSeq (protein) NP_002805 NP_001157649 Location (UCSC) Chr X:
107.33 – 107.33 Mb Chr X:
140.95 – 140.96 Mb PubMed search

26S proteasome non-ATPase regulatory subunit 10 is an enzyme that in humans is encoded by the PSMD10 gene.

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.

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