Examples
- In 2003, bortezomib was the first proteasome inhibitor to be approved for use in the U.S.
- Disulfiram has been proposed as another proteasome inhibitor.
- Epigallocatechin-3-gallate has also been proposed.
- Salinosporamide A has started clinical trials for multiple myeloma.
- carfilzomib was approved by the FDA for relapsed and refractory multiple myeloma on 20 July 2012.
- ONX 0912, CEP-18770, and MLN9708 have also started clinical trials.
- Epoxomicin is a naturally-occurring selective inhibitor.
- MG132 is a synthesized peptide commonly used for in vitro studies.
Read more about this topic: Proteasome Inhibitor
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