Promyelocytic Leukemia Protein
Gene Ontology | |
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Molecular function | • DNA binding • transcription coactivator activity • protein binding • zinc ion binding • ubiquitin protein ligase binding • SUMO binding • protein homodimerization activity • SMAD binding • protein heterodimerization activity • cobalt ion binding |
Cellular component | • nucleus • nucleoplasm • nucleolus • cytoplasm • cytosol • nuclear matrix • PML body • early endosome membrane • nuclear membrane • extrinsic to endoplasmic reticulum membrane |
Biological process | • response to hypoxia • regulation of protein phosphorylation • positive regulation of defense response to virus by host • transcription, DNA-dependent • regulation of transcription, DNA-dependent • protein complex assembly • protein targeting • induction of apoptosis • activation of cysteine-type endopeptidase activity involved in apoptotic process • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • cell cycle arrest • transforming growth factor beta receptor signaling pathway • common-partner SMAD protein phosphorylation • SMAD protein import into nucleus • negative regulation of cell proliferation • intrinsic apoptotic signaling pathway in response to DNA damage • response to UV • response to gamma radiation • regulation of calcium ion transport into cytosol • negative regulation of angiogenesis • virus-host interaction • cytokine-mediated signaling pathway • myeloid cell differentiation • negative regulation of cell growth • PML body organization • positive regulation of histone deacetylation • negative regulation of telomere maintenance via telomerase • endoplasmic reticulum calcium ion homeostasis • negative regulation of translation in response to oxidative stress • response to cytokine stimulus • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • proteasomal ubiquitin-dependent protein catabolic process • cell fate commitment • regulation of MHC class I biosynthetic process • negative regulation of transcription, DNA-dependent • negative regulation of mitotic cell cycle • retinoic acid receptor signaling pathway • protein stabilization • maintenance of protein location in nucleus • defense response to virus • negative regulation of telomerase activity • interferon-gamma-mediated signaling pathway • branching involved in mammary gland duct morphogenesis • cellular senescence • negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process • regulation of double-strand break repair • positive regulation of extrinsic apoptotic signaling pathway |
Sources: Amigo / QuickGO |
74.29 – 74.34 Mb
58.22 – 58.25 Mb
Probable transcription factor PML is a tumor suppressor protein that in humans is encoded by the PML gene.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies (Nuclear dots) where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
Read more about Promyelocytic Leukemia Protein: Interactions, See Also
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