Promyelocytic Leukemia Protein

Promyelocytic Leukemia Protein

Identifiers Symbols PML; MYL; PP8675; RNF71; TRIM19 External IDs OMIM: 102578 MGI: 104662 HomoloGene: 13245 GeneCards: PML Gene

Gene Ontology
Molecular function DNA binding
transcription coactivator activity
protein binding
zinc ion binding
ubiquitin protein ligase binding
SUMO binding
protein homodimerization activity
SMAD binding
protein heterodimerization activity
cobalt ion binding
Cellular component nucleus
nucleoplasm
nucleolus
cytoplasm
cytosol
nuclear matrix
PML body
early endosome membrane
nuclear membrane
extrinsic to endoplasmic reticulum membrane
Biological process response to hypoxia
regulation of protein phosphorylation
positive regulation of defense response to virus by host
transcription, DNA-dependent
regulation of transcription, DNA-dependent
protein complex assembly
protein targeting
induction of apoptosis
activation of cysteine-type endopeptidase activity involved in apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
cell cycle arrest
transforming growth factor beta receptor signaling pathway
common-partner SMAD protein phosphorylation
SMAD protein import into nucleus
negative regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
response to UV
response to gamma radiation
regulation of calcium ion transport into cytosol
negative regulation of angiogenesis
virus-host interaction
cytokine-mediated signaling pathway
myeloid cell differentiation
negative regulation of cell growth
PML body organization
positive regulation of histone deacetylation
negative regulation of telomere maintenance via telomerase
endoplasmic reticulum calcium ion homeostasis
negative regulation of translation in response to oxidative stress
response to cytokine stimulus
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
proteasomal ubiquitin-dependent protein catabolic process
cell fate commitment
regulation of MHC class I biosynthetic process
negative regulation of transcription, DNA-dependent
negative regulation of mitotic cell cycle
retinoic acid receptor signaling pathway
protein stabilization
maintenance of protein location in nucleus
defense response to virus
negative regulation of telomerase activity
interferon-gamma-mediated signaling pathway
branching involved in mammary gland duct morphogenesis
cellular senescence
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of double-strand break repair
positive regulation of extrinsic apoptotic signaling pathway
Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5371 18854 Ensembl ENSG00000140464 ENSMUSG00000036986 UniProt P29590 Q60953 RefSeq (mRNA) NM_002675 NM_008884 RefSeq (protein) NP_002666 NP_032910 Location (UCSC) Chr 15:
74.29 – 74.34 Mb Chr 9:
58.22 – 58.25 Mb PubMed search

Probable transcription factor PML is a tumor suppressor protein that in humans is encoded by the PML gene.

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies (Nuclear dots) where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

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