Biosynthesis
Proline is biosynthetically derived from the amino acid -glutamate and its immediate precursor is the imino acid (S)-1-pyrroline-5-carboxylate (P5C). Enzymes involved in a typical biosynthesis include:
- Glutamate 5-kinase, Glutamate 1-kinase (ATP-dependent)
- Glutamate dehydrogenase (requires NADH or NADPH)
- Pyrroline-5-carboxylate reductase (requires NADH or NADPH)
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