PRKRA

Identifiers Symbols PRKRA; DYT16; PACT; RAX External IDs OMIM: 603424 MGI: 1344375 HomoloGene: 2738 GeneCards: PRKRA Gene

Gene Ontology
Molecular function	• double-stranded RNA binding • protein binding • enzyme activator activity • protein homodimerization activity
Cellular component	• cytoplasm • cytosol • perinuclear region of cytoplasm
Biological process	• protein phosphorylation • induction of apoptosis • response to stress • immune response • negative regulation of cell proliferation • response to virus • gene expression • production of siRNA involved in RNA interference • outer ear morphogenesis • middle ear morphogenesis • positive regulation of catalytic activity • skeletal system morphogenesis
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8575 23992 Ensembl ENSG00000180228 ENSMUSG00000002731 UniProt O75569 Q9WTX2 RefSeq (mRNA) NM_001139517 NM_011871 RefSeq (protein) NP_001132989 NP_036001 Location (UCSC) Chr 2:
179.3 – 179.32 Mb Chr 2:
76.63 – 76.65 Mb PubMed search

Protein kinase, interferon-inducible double stranded RNA dependent activator, also known as interferon-inducible double stranded RNA-dependent protein kinase activator A or Protein ACTivator of the interferon-induced protein kinase (PACT) is a protein that in humans is encoded by the PRKRA gene. PACT heterodimerizes with and activates protein kinase R. PRKRA mutations have been linked to a rare form of dystonia parkinsonism.