PRKCI

PRKCI

Identifiers Symbols PRKCI; DXS1179E; PKCI; nPKC-iota External IDs OMIM: 600539 MGI: 99260 HomoloGene: 37667 ChEMBL: 2598 GeneCards: PRKCI Gene EC number 2.7.11.13

Gene Ontology
Molecular function	• protein kinase activity • protein serine/threonine kinase activity • protein kinase C activity • protein binding • ATP binding • phospholipid binding • zinc ion binding • protein domain specific binding
Cellular component	• polarisome • nucleus • endosome • cytosol • plasma membrane • apical plasma membrane • cell leading edge • Schmidt-Lanterman incisure
Biological process	• protein phosphorylation • protein targeting to membrane • cytoskeleton organization • actin filament organization • positive regulation of neuron projection development • cellular membrane organization • vesicle-mediated transport • cell migration • cellular response to insulin stimulus • cell junction assembly • negative regulation of glial cell apoptotic process • establishment of apical/basal cell polarity • intracellular signal transduction • eye photoreceptor cell development • negative regulation of apoptotic process • negative regulation of neuron apoptotic process • establishment or maintenance of epithelial cell apical/basal polarity • cell-cell junction organization • positive regulation of glucose import • secretion • neurotrophin TRK receptor signaling pathway • Golgi vesicle budding • positive regulation of NF-kappaB transcription factor activity • positive regulation of glial cell proliferation • response to interleukin-1 • tight junction assembly • positive regulation of establishment of protein localization to plasma membrane • positive regulation of endothelial cell apoptotic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5584 18759 Ensembl ENSG00000163558 ENSMUSG00000037643 UniProt P41743 Q62074 RefSeq (mRNA) NM_002740 NM_008857 RefSeq (protein) NP_002731 NP_032883 Location (UCSC) Chr 3:
169.94 – 170.02 Mb Chr 3:
31 – 31.05 Mb PubMed search

Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.