PRKCG

PRKCG

Identifiers Symbols PRKCG; PKC-gamma; PKCC; PKCG; SCA14 External IDs OMIM: 176980 MGI: 97597 HomoloGene: 20602 ChEMBL: 2938 GeneCards: PRKCG Gene EC number 2.7.11.13

Gene Ontology
Molecular function	• protein kinase activity • protein kinase C activity • calcium-dependent protein kinase C activity • ATP binding • zinc ion binding
Cellular component	• nucleus • cytosol • plasma membrane • cell junction • dendrite • perinuclear region of cytoplasm • synaptic membrane
Biological process	• protein phosphorylation • signal transduction • epidermal growth factor receptor signaling pathway • activation of phospholipase C activity • synaptic transmission • blood coagulation • learning or memory • chemosensory behavior • cell death • fibroblast growth factor receptor signaling pathway • phosphorylation • platelet activation • negative regulation of protein ubiquitination • positive regulation of mismatch repair • intracellular signal transduction • negative regulation of protein catabolic process • response to morphine • negative regulation of neuron apoptotic process • innate immune response • protein autophosphorylation • neurotrophin TRK receptor signaling pathway • response to pain • innervation
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5582 18752 Ensembl ENSG00000126583 ENSMUSG00000078816 UniProt P05129 P63318 RefSeq (mRNA) NM_002739 NM_011102 RefSeq (protein) NP_002730 NP_035232 Location (UCSC) Chr 19:
54.38 – 54.41 Mb Chr 7:
3.3 – 3.33 Mb PubMed search

Protein kinase C gamma type is an enzyme that in humans is encoded by the PRKCG gene.

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).