PPP1CA

PPP1CA

Identifiers Symbols PPP1CA; PP-1A; PP1A; PP1alpha; PPP1A External IDs OMIM: 176875 MGI: 103016 HomoloGene: 105262 ChEMBL: 2164 GeneCards: PPP1CA Gene EC number 3.1.3.16

Gene Ontology
Molecular function	• protein serine/threonine phosphatase activity • protein binding • ribonucleoprotein complex binding • metal ion binding
Cellular component	• protein phosphatase type 1 complex • nucleus • nucleolus • cytoplasm • cytosol • glycogen granule • dendritic spine • perikaryon • MLL5-L complex • PTW/PP1 phosphatase complex
Biological process	• glycogen metabolic process • regulation of glycogen biosynthetic process • regulation of glycogen catabolic process • protein dephosphorylation • lipid metabolic process • cell cycle • transforming growth factor beta receptor signaling pathway • triglyceride catabolic process • lung development • negative regulation of transforming growth factor beta receptor signaling pathway • small molecule metabolic process • branching morphogenesis of an epithelial tube • cell division
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5499 19045 Ensembl ENSG00000172531 ENSMUSG00000040385 UniProt P62136 P62137 RefSeq (mRNA) NM_001008709 NM_031868 RefSeq (protein) NP_001008709 NP_114074 Location (UCSC) Chr 11:
67.17 – 67.19 Mb Chr 19:
4.19 – 4.2 Mb PubMed search

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the PPP1CA gene.

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.