PPM1A

PPM1A

Identifiers Symbols PPM1A; PP2C-ALPHA; PP2CA; PP2Calpha External IDs OMIM: 606108 MGI: 99878 HomoloGene: 56428 ChEMBL: 2437 GeneCards: PPM1A Gene EC number 3.1.3.16

Gene Ontology
Molecular function	• magnesium ion binding • protein serine/threonine phosphatase activity • signal transducer activity • protein binding • manganese ion binding • calmodulin-dependent protein phosphatase activity • R-SMAD binding
Cellular component	• nucleus • nucleoplasm • cytosol
Biological process	• negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-dependent • transcription initiation from RNA polymerase II promoter • cell cycle arrest • transforming growth factor beta receptor signaling pathway • insulin receptor signaling pathway • gene expression • negative regulation of SMAD protein complex assembly • Wnt receptor signaling pathway • dephosphorylation • positive regulation of Wnt receptor signaling pathway • negative regulation of transforming growth factor beta receptor signaling pathway • peptidyl-threonine dephosphorylation • positive regulation of I-kappaB kinase/NF-kappaB cascade • positive regulation of transcription, DNA-dependent
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5494 19042 Ensembl ENSG00000100614 ENSMUSG00000021096 UniProt P35813 P49443 RefSeq (mRNA) NM_021003 NM_008910 RefSeq (protein) NP_066283 NP_032936 Location (UCSC) Chr 14:
60.71 – 60.77 Mb Chr 12:
72.76 – 72.79 Mb PubMed search

Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene.

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding two distinct isoforms have been described.