Ppm1a

PPM1A

Identifiers Symbols PPM1A; PP2C-ALPHA; PP2CA; PP2Calpha External IDs OMIM: 606108 MGI: 99878 HomoloGene: 56428 ChEMBL: 2437 GeneCards: PPM1A Gene EC number 3.1.3.16

Gene Ontology
Molecular function	• magnesium ion binding • protein serine/threonine phosphatase activity • signal transducer activity • protein binding • manganese ion binding • calmodulin-dependent protein phosphatase activity • R-SMAD binding
Cellular component	• nucleus • nucleoplasm • cytosol
Biological process	• negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-dependent • transcription initiation from RNA polymerase II promoter • cell cycle arrest • transforming growth factor beta receptor signaling pathway • insulin receptor signaling pathway • gene expression • negative regulation of SMAD protein complex assembly • Wnt receptor signaling pathway • dephosphorylation • positive regulation of Wnt receptor signaling pathway • negative regulation of transforming growth factor beta receptor signaling pathway • peptidyl-threonine dephosphorylation • positive regulation of I-kappaB kinase/NF-kappaB cascade • positive regulation of transcription, DNA-dependent
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5494 19042 Ensembl ENSG00000100614 ENSMUSG00000021096 UniProt P35813 P49443 RefSeq (mRNA) NM_021003 NM_008910 RefSeq (protein) NP_066283 NP_032936 Location (UCSC) Chr 14:
60.71 – 60.77 Mb Chr 12:
72.76 – 72.79 Mb PubMed search

Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene.