Clinical Significance
Lesions affecting the primary somatosensory cortex produce characteristic symptoms including: agraphesthesia, astereognosia, loss of vibration, proprioception, and fine touch (because the third-order neuron of the medial-lemniscal pathway cannot synapse in the cortex). It can also produce hemineglect, if it affects the non-dominant hemisphere.
It could also reduce nociception, thermoception, and crude touch, but, since information from the spinothalamic tract is interpreted mainly by other areas of the brain (see insular cortex and cingulate gyrus), it is not as relevant as the other symptoms.
Read more about this topic: Postcentral Gyrus
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