Polynucleotide Phosphorylase - Model Organisms

Model Organisms

Pnpt1 knockout mouse phenotype
Characteristic Phenotype
Homozygote viability Abnormal
Recessive lethal study Abnormal
Fertility Normal
Body weight Normal
Anxiety Normal
Neurological assessment Normal
Grip strength Normal
Hot plate Normal
Dysmorphology Normal
Indirect calorimetry Normal
Glucose tolerance test Normal
Auditory brainstem response Normal
DEXA Normal
Radiography Normal
Body temperature Normal
Eye morphology Normal
Clinical chemistry Normal
Plasma immunoglobulins Normal
Haematology Normal
Peripheral blood lymphocytes Normal
Micronucleus test Normal
Heart weight Normal
Skin Histopathology Normal
Brain histopathology Normal
Salmonella infection Normal
Citrobacter infection Normal
All tests and analysis from

Model organisms have been used in the study of PNPT1 function. A conditional knockout mouse line, called Pnpt1tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty six tests were carried out on mutant mice and two significant abnormalities were observed. No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals.

Human PNPase I
Identifiers
Symbol PNPASE
Alt. symbols PNPase, OLD35, old-35
Entrez 87178
HUGO 23166
OMIM 610316
PDB 1E3P
RefSeq NM_033109
UniProt Q8TCS8
Other data
EC number 2.7.7.8
Locus Chr. 2 p15

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