Poletti is an Italian and Swiss surname. Holders include (alphabetically):
- Charles Poletti (1903–2002), Italian-American politician
- Fabrizio Poletti (born 1943), Italian footballer
- Felix Poletti (born 1965), Swiss skeleton racer
- Kurt Poletti, Swiss bobsledder
- Lina Poletti (1885–1971), Italian feminist
- Luigi Poletti (mathematician) (1864–1967), Italian poet and mathematician
- Luigi Poletti (architect) (1792–1869), Italian architect
- Ugo Poletti (1914–1997), Italian cardinal
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