PKC Alpha
| Gene Ontology | |
|---|---|
| Molecular function | • protein kinase activity • protein serine/threonine kinase activity • protein kinase C activity • calcium-dependent protein kinase C activity • protein binding • ATP binding • zinc ion binding • enzyme binding • histone kinase activity (H3-T6 specific) |
| Cellular component | • photoreceptor outer segment • nucleoplasm • cytoplasm • endoplasmic reticulum • cytosol • plasma membrane • dendrite • mitochondrial membrane • neuronal cell body • perinuclear region of cytoplasm |
| Biological process | • inactivation of MAPK activity • angiogenesis • positive regulation of protein phosphorylation • positive regulation of endothelial cell proliferation • regulation of the force of heart contraction • chondrocyte differentiation • desmosome assembly • energy reserve metabolic process • protein phosphorylation • cellular calcium ion homeostasis • regulation of muscle contraction • cell adhesion • signal transduction • epidermal growth factor receptor signaling pathway • activation of adenylate cyclase activity • negative regulation of adenylate cyclase activity • activation of phospholipase C activity • synaptic transmission • blood coagulation • negative regulation of cell proliferation • fibroblast growth factor receptor signaling pathway • gene expression • positive regulation of endothelial cell migration • positive regulation of cardiac muscle hypertrophy • RNA metabolic process • mRNA metabolic process • platelet activation • neutrophil chemotaxis • positive regulation of lipopolysaccharide-mediated signaling pathway • negative regulation of glial cell apoptotic process • histone H3-T6 phosphorylation • positive regulation of blood vessel endothelial cell migration • small molecule metabolic process • innate immune response • positive regulation of macrophage differentiation • positive regulation of angiogenesis • positive regulation of cell adhesion • positive regulation of mitotic cell cycle • negative regulation of glucose import • negative regulation of insulin receptor signaling pathway • neurotrophin TRK receptor signaling pathway • positive regulation of inflammatory response • regulation of peptidyl-tyrosine phosphorylation • regulation of insulin secretion • induction of positive chemotaxis • positive regulation of ERK1 and ERK2 cascade • response to interleukin-1 • cellular response to carbohydrate stimulus • regulation of platelet aggregation • apoptotic signaling pathway • intrinsic apoptotic signaling pathway • positive regulation of dense core granule biogenesis |
| Sources: Amigo / QuickGO | |
64.3 – 64.81 Mb
107.93 – 108.34 Mb
Protein kinase C alpha (PKCα), also known as PRKCA, refers to both a human gene and the protein that is encoded by it. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca2+ handling in myocytes.
Read more about PKC Alpha: Background, Regulation, Secondary Protein Structure Determination, Memory and PTSD, Future Research Prospects, Genes Associated With PKC Alpha, Interactions
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