Pituitary-specific Positive Transcription Factor 1

Pituitary-specific Positive Transcription Factor 1

Identifiers Symbols POU1F1; CPHD1; GHF-1; PIT1; POU1F1a; Pit-1 External IDs OMIM: 173110 MGI: 97588 HomoloGene: 259 GeneCards: POU1F1 Gene

Gene Ontology
Molecular function	• RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription • RNA polymerase II activating transcription factor binding • RNA polymerase II transcription coactivator activity • chromatin binding • sequence-specific DNA binding transcription factor activity • transcription corepressor activity • sequence-specific DNA binding
Cellular component	• nucleus • nucleolus • cytoplasm
Biological process	• negative regulation of transcription from RNA polymerase II promoter • cell fate specification • transcription from RNA polymerase II promoter • positive regulation of cell proliferation • negative regulation of cell proliferation • determination of adult lifespan • B cell differentiation • positive regulation of inositol trisphosphate biosynthetic process • positive regulation of multicellular organism growth • regulation of insulin-like growth factor receptor signaling pathway • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • nuclear transport • somatotropin secreting cell development
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5449 18736 Ensembl ENSG00000064835 ENSMUSG00000004842 UniProt P28069 Q00286 RefSeq (mRNA) NM_000306 NM_008849 RefSeq (protein) NP_000297 NP_032875 Location (UCSC) Chr 3:
87.31 – 87.33 Mb Chr 16:
65.52 – 65.54 Mb PubMed search

POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), also known as POU1F1, is a transcription factor for growth hormone.

PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 (MIM 164175) of mammals, and Unc-86 of C. elegans (Herr et al., 1988). PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone (GH; MIM 139250) and prolactin (PRL; MIM 176760). PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit (TSHB; MIM 188540) by thyrotropin-releasing hormone (TRH; MIM 257120) and cyclic AMP.