PIN1

PIN1

Identifiers Symbols PIN1; DOD; UBL5 External IDs OMIM: 601052 MGI: 1346036 HomoloGene: 4531 ChEMBL: 2288 GeneCards: PIN1 Gene EC number 5.2.1.8

Gene Ontology
Molecular function	• peptidyl-prolyl cis-trans isomerase activity • protein binding • mitogen-activated protein kinase kinase binding • GTPase activating protein binding • phosphoserine binding • phosphothreonine binding
Cellular component	• nucleus • nucleoplasm • cytoplasm • nuclear speck • midbody
Biological process	• protein peptidyl-prolyl isomerization • positive regulation of protein phosphorylation • protein folding • cell cycle • regulation of mitosis • cytokine-mediated signaling pathway • negative regulation of transforming growth factor beta receptor signaling pathway • positive regulation of Rho GTPase activity • regulation of cytokinesis • negative regulation of type I interferon production • regulation of cell proliferation • innate immune response • positive regulation of ubiquitin-protein ligase activity • regulation of pathway-restricted SMAD protein phosphorylation • negative regulation of ERK1 and ERK2 cascade • negative regulation of cell motility
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5300 23988 Ensembl ENSG00000127445 ENSMUSG00000032171 UniProt Q13526 Q9QUR7 RefSeq (mRNA) NM_006221 NM_023371 RefSeq (protein) NP_006212 NP_075860 Location (UCSC) Chr 19:
9.95 – 9.96 Mb Chr 9:
20.65 – 20.67 Mb PubMed search

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 is an enzyme that in humans is encoded by the PIN1 gene. (Not to be confused with PIN1 (Pin-formed 1), an auxin transporter in Arabidopsis thaliana.)

Pin 1, or peptidyl-prolyl cis/trans isomerase (PPIase), isomerizes only phospho-Serine/Threonine-Proline motifs. The enzyme binds to a subset of proteins and thus plays a role as a post phosphorylation control in regulating protein function. Studies have shown that the deregulation of Pin1 may play a pivotal role in various diseases. Notably, the up-regulation of Pin1 may be implicated in certain cancers, and the down-regulation of Pin1 may be implicated in Alzheimer's disease. Inhibitors of Pin1 may have therapeutic implications for cancer and immune disorders.