PIAS1
Gene Ontology | |
---|---|
Molecular function | • DNA binding • transcription coactivator activity • transcription corepressor activity • protein binding • zinc ion binding • SUMO ligase activity • enzyme binding • protein domain specific binding • ubiquitin protein ligase binding • androgen receptor binding |
Cellular component | • nucleus • nucleoplasm • PML body • nuclear speck |
Biological process | • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-dependent • JAK-STAT cascade • spermatogenesis • protein sumoylation • cytokine-mediated signaling pathway • androgen receptor signaling pathway • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • positive regulation of protein sumoylation • regulation of cell proliferation • positive regulation of transcription, DNA-dependent • positive regulation of smooth muscle cell differentiation • interferon-gamma-mediated signaling pathway • regulation of interferon-gamma-mediated signaling pathway • protein-DNA complex assembly |
Sources: Amigo / QuickGO |
68.35 – 68.48 Mb
62.88 – 62.98 Mb
E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.
This gene encodes a member of the mammalian PIAS family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.
Read more about PIAS1: Interactions