PIAS1

PIAS1

Identifiers Symbols PIAS1; DDXBP1; GBP; GU/RH-II; ZMIZ3 External IDs OMIM: 603566 MGI: 1913125 HomoloGene: 22953 GeneCards: PIAS1 Gene

Gene Ontology
Molecular function DNA binding
transcription coactivator activity
transcription corepressor activity
protein binding
zinc ion binding
SUMO ligase activity
enzyme binding
protein domain specific binding
ubiquitin protein ligase binding
androgen receptor binding
Cellular component nucleus
nucleoplasm
PML body
nuclear speck
Biological process negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-dependent
JAK-STAT cascade
spermatogenesis
protein sumoylation
cytokine-mediated signaling pathway
androgen receptor signaling pathway
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein sumoylation
regulation of cell proliferation
positive regulation of transcription, DNA-dependent
positive regulation of smooth muscle cell differentiation
interferon-gamma-mediated signaling pathway
regulation of interferon-gamma-mediated signaling pathway
protein-DNA complex assembly
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8554 56469 Ensembl ENSG00000033800 ENSMUSG00000032405 UniProt O75925 O88907 RefSeq (mRNA) NM_016166 NM_019663 RefSeq (protein) NP_057250 NP_062637 Location (UCSC) Chr 15:
68.35 – 68.48 Mb Chr 9:
62.88 – 62.98 Mb PubMed search

E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.

This gene encodes a member of the mammalian PIAS family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis.

Read more about PIAS1:  Interactions