Phosphatidylglycerol - Biosynthesis

Biosynthesis

L-glycerol-3-phosphate is activated by a CTP and pyrophosphate is cleaved off resulting in CDP-diglycerol. Glycerol-3-phosphate is attached to CDP-diglycerol and phosphatidylglycerol phosphate is formed, while CMP is released. The phosphate group is hydrolysed forming phosphatidylglycerol. Two phosphatidylglycerols form cardiolipin, the constituent molecule of the mitochondrial inner membrane.

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