History
Scientists associated with the biotech company Stratagene, based in La Jolla, California, discovered the superiority of Pfu over Taq in 1991. They published their work as Lundberg et al., "A High Fidelity Thermostable DNA Polymerase Isolated from Pyrococcus Furiosus," Strategies 4:34-35 (1991) and Gene in December of that year (Gene. 1991 Dec 12;108(1):1-6). U.S. Patent 5,489,523 was granted over exonuclease-deficient Pfu in February 1996 while U.S. and (1991)Patent 5,545,552 over Pfu itself was granted in August 1996.
Read more about this topic: Pfu DNA Polymerase
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