Research
Michaelis worked primarily on the inheritance and segregation of cytoplasmic mutations in Epilobium, a genus related to Oenothera. He calculated in 1955/1956 the statistical probability of the segregation of two different types of plastids under different conditions. With further research Michaelis concluded that segregation of a mutant plastid could be the only cause of the observed variegation in the species.
After this Michaelis examined thirty cases of plastid variegation where no mixed cells were found. He proposed that mutant and non-mutant plastids were still segregating in early mitotic divisions. He suggested two possible ways the plastid could influence one another: (1) The mutant plastid might manufacture a substance that damaged the normal plastids during the maturation process. (2) The normal plastid might manufacture a substance that would allow the mutant form to develop normally.
Theory predicted that the two types could be distinguished clearly by an examination of the distribution of mutant and normal cells. Michealis found clear examples of both types of mutation in his material and published his work in 1956.
Michaelis firmly believed in complex unity in the cytoplasm, but he rejected simplistic notions such as the plasma gene or that the cause of cytoplasmic inheritance was solely due to plastids and mitochondria.
Read more about this topic: Peter Michaelis
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