PD-L1

PD-L1

Identifiers Symbols CD274; B7-H; B7H1; PD-L1; PDCD1L1; PDCD1LG1; PDL1 External IDs OMIM: 605402 MGI: 1926446 HomoloGene: 8560 GeneCards: CD274 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• plasma membrane • external side of plasma membrane • endomembrane system • integral to membrane • extracellular vesicular exosome
Biological process	• immune response • signal transduction • cell surface receptor signaling pathway • T cell costimulation • positive regulation of T cell proliferation • negative regulation of T cell proliferation • positive regulation of interleukin-10 secretion
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 29126 60533 Ensembl ENSG00000120217 ENSMUSG00000016496 UniProt Q9NZQ7 Q9EP73 RefSeq (mRNA) NM_001267706 NM_021893 RefSeq (protein) NP_001254635 NP_068693 Location (UCSC) Chr 9:
5.45 – 5.47 Mb Chr 19:
29.37 – 29.39 Mb PubMed search

Programmed cell death 1 ligand 1 (PD-L1) also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene.

Programmed death ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. Normally the immune system reacts to foreign antigens where there is some accumulation in the lymph nodes or spleen which triggers a proliferation of antigen-specific CD8+ T cell. The formation of PD-1 receptor / PD-L1 ligand complex transmits an inhibitory signal which reduces the proliferation of these CD8+ T cells at the lymph nodes and supplementary to that PD-1 is also able to control the accumulation of foreign antigen specific T cells in the lymph nodes through apoptosis which is further mediated by a lower regulation of the gene Bcl-2.