PAX6

PAX6

Identifiers Symbols PAX6; AN; AN2; D11S812E; MGDA; WAGR External IDs OMIM: 607108 MGI: 97490 HomoloGene: 1212 GeneCards: PAX6 Gene

Gene Ontology
Molecular function	• RNA polymerase II core promoter sequence-specific DNA binding • sequence-specific DNA binding RNA polymerase II transcription factor activity • DNA binding • AT DNA binding • double-stranded DNA binding • sequence-specific DNA binding transcription factor activity • ubiquitin-protein ligase activity • protein binding • transcription factor binding • protein kinase binding • ubiquitin protein ligase binding • histone acetyltransferase binding • co-SMAD binding • R-SMAD binding • HMG box domain binding
Cellular component	• nuclear chromatin • nucleus • nucleolus • cytoplasm
Biological process	• blood vessel development • eye development • cell fate determination • neuron migration • positive regulation of neuroblast proliferation • lens development in camera-type eye • pancreatic A cell development • transcription from RNA polymerase II promoter • smoothened signaling pathway • axon guidance • central nervous system development • salivary gland morphogenesis • visual perception • response to wounding • organ morphogenesis • dorsal/ventral axis specification • positive regulation of gene expression • protein ubiquitination • oligodendrocyte cell fate specification • cerebral cortex regionalization • forebrain anterior/posterior pattern specification • forebrain dorsal/ventral pattern formation • commitment of neuronal cell to specific neuron type in forebrain • forebrain-midbrain boundary formation • regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification • regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification • regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment • pituitary gland development • signal transduction involved in regulation of gene expression • keratinocyte differentiation • regulation of cell migration • positive regulation of epithelial cell differentiation • hindbrain development • lacrimal gland development • protein localization to organelle • eye photoreceptor cell development • glucose homeostasis • positive regulation of cell fate specification • negative regulation of neuron differentiation • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • regulation of timing of cell differentiation • embryonic camera-type eye morphogenesis • neuron fate commitment • astrocyte differentiation • negative regulation of epithelial cell proliferation • negative regulation of neurogenesis • iris morphogenesis • cornea development in camera-type eye
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5080 18508 Ensembl ENSG00000007372 ENSMUSG00000027168 UniProt P26367 P63015 RefSeq (mRNA) NM_000280 NM_001244198 RefSeq (protein) NP_000271 NP_001231127 Location (UCSC) Chr 11:
31.81 – 31.84 Mb Chr 2:
105.67 – 105.7 Mb PubMed search

Paired box protein Pax-6 also known as aniridia type II protein (AN2) or oculorhombin is a protein that in humans is encoded by the PAX6 gene.