Pathophysiology of Chronic Fatigue Syndrome - Gene Expression and Polymorphisms

Gene Expression and Polymorphisms

CFS-related abnormalities in gene expression have been studied. Changes in genes involved in transport (both vesicle-mediated and protein transport), metabolism, immune regulation, neuronal function, mitochondrial function, apoptosis and other processes have been reported. The CDC has said these changes could be involved in CFS. Some of the symptoms of gene expression differences may be treatable with existing drugs. Some researchers think gene expression studies could make possible better categorization of CFS and even help with differential diagnosis.

An abnormally large and rapid mRNA activation of sensory, immune/cytokine and adrenergic receptors have been implicated in the post-exertional symptoms experienced by CFS patients after exercise.

A 2007 review stated that certain genetic polymorphisms might be regarded as predisposing factors. Studies have shown genetic differences in genes of CFS patients and healthy controls in the central nervous, endocrine, immune and cardiovascular systems.