The Pascagoula Amtrak station is a train station in Pascagoula, Mississippi, United States served by Amtrak, the national railroad passenger system. Service has been suspended since Hurricane Katrina struck Pascagoula in 2005.
Pascagoula station was originally the Louisville and Nashville Railroad Depot. It was restored during the 1970s and converted into an Amtrak station. The station is on both the National Register of Historic Places, and the Mississippi State Department of Archives and History. In addition, the station serves as an art gallery owned by the Singing River Art Association.