Palindrome - Biological Structures

Biological Structures

In most genomes or sets of genetic instructions, palindromic motifs are found. The meaning of palindrome in the context of genetics is slightly different, however, from the definition used for words and sentences. Since the DNA is formed by two paired strands of nucleotides, and the nucleotides always pair in the same way (Adenine (A) with Thymine (T), Cytosine (C) with Guanine (G)), a (single-stranded) sequence of DNA is said to be a palindrome if it is equal to its complementary sequence read backward. For example, the sequence ACCTAGGT is palindromic because its complement is TGGATCCA, which is equal to the original sequence in reverse complement.

A palindromic DNA sequence may form a hairpin. Palindromic motifs are made by the order of the nucleotides that specify the complex chemicals (proteins) that, as a result of those genetic instructions, the cell is to produce. They have been specially researched in bacterial chromosomes and in the so-called Bacterial Interspersed Mosaic Elements (BIMEs) scattered over them. Recently a research genome sequencing project discovered that many of the bases on the Y-chromosome are arranged as palindromes. A palindrome structure allows the Y-chromosome to repair itself by bending over at the middle if one side is damaged.

It is believed that palindromes frequently are also found in proteins, but their role in the protein function is not clearly known. It has recently been suggested that the prevalence existence of palindromes in peptides might be related to the prevalence of low-complexity regions in proteins, as palindromes frequently are associated with low-complexity sequences. Their prevalence might also be related to an alpha helical formation propensity of these sequences, or in formation of proteins/protein complexes.