Two-step Oxidation of Alcohols To Acids Via Isolated Aldehydes
As a lot of the aforementioned conditions for the oxidations of primary alcohols to acids are harsh and not compatible with common protection groups, organic chemists often use a two-step procedure for the oxidation to acids. The primary alcohol is oxidized to an aldehyde using one of the many existing procedures (e.g. IBX oxidation, Dess-Martin periodinane). The aldehyde can then be subjected to the conditions of the Pinnick oxidation using sodium chlorite. This sequence is often used in natural product synthesis, Nicolaou et al. applied it in their synthesis of Platencin.
Read more about this topic: Oxidation Of Primary Alcohols To Carboxylic Acids
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