Disorders
When there is insufficient nutrient minerals or osteoblast dysfunction, the osteoid does not mineralize properly, and it accumulates. The resultant disorder is termed rickets in children and osteomalacia in adults.
In very rare cases, primitive transformed cells of mesenchymal origin exhibit osteoblastic differentiation and produce malignant osteoid, which results in the formation of a malignant primary bone tumor known as osteosarcoma or osteogenic sarcoma. This malignancy most often develops in adolescence during periods of rapid osteoid formation (commonly referred to as growth spurts).
Read more about this topic: Osteoid
Famous quotes containing the word disorders:
“A car can massage organs which no masseur can reach. It is the one remedy for the disorders of the great sympathetic nervous system.”
—Jean Cocteau (1889–1963)
“It no longer makes sense to speak of “feeding problems” or “sleep problems” or “negative behavior” is if they were distinct categories, but to speak of “problems of development” and to search for the meaning of feeding and sleep disturbances or behavior disorders in the developmental phase which has produced them.”
—Selma H. Fraiberg (20th century)